Medically Reviewed By
On March 24, 2025
Written By
On March 24, 2025
Methamphetamine is a powerful and controlled substance, and an overdose occurs when someone takes too much of it, leading to severe and potentially life-threatening symptoms.[1] If someone you know exhibits the signs of methamphetamine overdose—such as rapid heart rate, agitation, confusion, seizures, or loss of consciousness—then seeking out emergency medical assistance is critical. Prompt intervention is crucial to prevent serious complications and increase the chances of a successful outcome.
Methamphetamine, commonly known as meth, is a powerful stimulant drug that affects the central nervous system.[2] It is chemically similar to amphetamine, a medication used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. However, methamphetamine is classified as a Schedule II controlled substance due to its high potential for abuse and addiction.[3]
Methamphetamine significantly increases dopamine release, a neurotransmitter linked to pleasure and reward, more so than similar stimulants.[4] This pronounced increase in dopamine not only produces euphoria, increased energy, and heightened alertness but also contributes to its reputation as a ‘party drug’ and its potential for intense psychological dependence and widespread misuse.
Methamphetamine can be consumed in various forms, including as a pill, powder, or crystal. It can be swallowed, snorted, smoked, or injected. The route of administration influences the speed and intensity of the drug’s effects. Smoking or injecting methamphetamine produces a rapid onset of euphoria, whereas swallowing or snorting it leads to a slower onset but longer-lasting effects.
Despite its short-term effects of euphoria and increased energy, methamphetamine poses numerous risks to both physical and mental health. Prolonged use or high doses of methamphetamine can lead to:[5]
Yes, it is possible to overdose on methamphetamine. Methamphetamine overdose occurs when someone takes too much of the drug, leading to dangerous and potentially life-threatening symptoms.[6]
Overdose can result from ingesting a large dose of methamphetamine at once or from using the drug in a way that leads to a buildup of toxic levels in the body. Methamphetamine overdose requires immediate medical attention and can be fatal if not treated promptly.
Signs and symptoms of a methamphetamine overdose can vary in severity but may include:[7]
It’s crucial to recognize the signs and symptoms of a methamphetamine overdose and seek immediate medical assistance by calling emergency services (e.g., 911) if you suspect someone is experiencing an overdose. Prompt medical intervention can help prevent serious complications and save lives.
Do not attempt to treat the person yourself. If the person stops breathing or shows signs of cardiac arrest, such as an irregular or stopped heartbeat, and you are trained in CPR, immediately begin chest compressions and rescue breaths. Continuously assess the situation and administer CPR until emergency responders arrive.
Methamphetamine overdose requires immediate medical attention to address potentially life-threatening symptoms and prevent serious complications. Treatment for methamphetamine overdose typically involves supportive care and may include:[8]
Yes, a methamphetamine overdose can be fatal if not treated promptly. The drug’s stimulant effects can lead to severe cardiovascular complications, hyperthermia, seizures, and other life-threatening conditions.
The time it takes to overdose on methamphetamine can vary depending on factors such as the dose consumed, the individual’s tolerance, and their overall health. In some cases, overdose symptoms can occur rapidly after ingesting a large amount of the drug, while in others, they may develop gradually over time with chronic use.
Several factors can increase the risk of a methamphetamine overdose, including:
Yes, a methamphetamine overdose can cause permanent damage to various organ systems, including the cardiovascular system, central nervous system, and kidneys. Prolonged exposure to high doses of methamphetamine can lead to long-term neurological deficits, cardiovascular complications, and renal impairment.
If you are concerned that a loved one is at risk of methamphetamine overdose, it’s essential to encourage them to seek professional help and support. Offer nonjudgmental support and encouragement to enter a substance abuse treatment program where they can receive comprehensive care and assistance in overcoming their addiction. Additionally, educate yourself about the signs of methamphetamine overdose and how to respond effectively in an emergency.
Here at Ascendant New York, we understand the importance of having access to accurate medical information you can trust, especially when you or a loved one is suffering from addiction. Find out more on our policy.
[1] National Institute on Drug Abuse. (2019, October). What is methamphetamine? National Institute on Drug Abuse. https://nida.nih.gov/publications/research-reports/methamphetamine/what-methamphetamine
[2] SAMHSA. (2022, August 19). Know the Risks of Meth. Www.samhsa.gov. https://www.samhsa.gov/meth
[3] National Drug Intelligence Center. (n.d.). Omaha (NE) Police Department. https://www.justice.gov/archive/ndic/pubs5/5049/5049p.pdf
[4] Lin, M., Sambo, D., & Khoshbouei, H. (2016). Methamphetamine Regulation of Firing Activity of Dopamine Neurons. The Journal of Neuroscience, 36(40), 10376–10391. https://doi.org/10.1523/JNEUROSCI.1392-16.2016
[5] National Institute on Drug Abuse. (2019, October). What are the long-term effects of methamphetamine misuse? National Institute on Drug Abuse. https://nida.nih.gov/publications/research-reports/methamphetamine/what-are-long-term-effects-methamphetamine-misuse
[6] Methamphetamine overdose Information | Mount Sinai – New York. (n.d.). Mount Sinai Health System. https://www.mountsinai.org/health-library/poison/methamphetamine-overdose
[7] METHAMPHETAMINE OVERDOSE (OVERAMPING). (n.d.). Retrieved April 11, 2024, from https://www.oregon.gov/oha/PH/HEALTHYENVIRONMENTS/TRACKINGASSESSMENT/ENVIRONMENTALHEALTHASSESSMENT/Documents/Methamphetamine-Overdose-Overview_Oregon_Dec2022.pdf
[8] Methamphetamine: Acute intoxication. UpToDate. (n.d.). https://www.uptodate.com/contents/methamphetamine-acute-intoxication